| Rancho Santa Margarita to Southern Pines (North Carolina) | 2,166.44 mi (3,486.54 km) |
| Rancho Santa Margarita to Southfield (Michigan) | 1,950.26 mi (3,138.65 km) |
| Rancho Santa Margarita to Southgate (Michigan) | 1,950.92 mi (3,139.70 km) |
| Rancho Santa Margarita to Southlake (Texas) | 1,179.97 mi (1,898.99 km) |
| Rancho Santa Margarita to Spanaway (Washington) | 963.96 mi (1,551.35 km) |
| Rancho Santa Margarita to Spanish Fork (Utah) | 555.40 mi (893.83 km) |
| Rancho Santa Margarita to Spanish Lake (Missouri) | 1,561.70 mi (2,513.31 km) |
| Rancho Santa Margarita to Spanish Springs (Nevada) | 431.79 mi (694.89 km) |
| Rancho Santa Margarita to Sparks (Nevada) | 426.97 mi (687.14 km) |
| Rancho Santa Margarita to Spartanburg (South Carolina) | 2,027.69 mi (3,263.24 km) |
| Rancho Santa Margarita to Spearfish (South Dakota) | 1,050.62 mi (1,690.81 km) |
| Rancho Santa Margarita to Speedway (Indiana) | 1,778.05 mi (2,861.49 km) |
| Rancho Santa Margarita to Spencer (Iowa) | 1,375.72 mi (2,214.01 km) |
| Rancho Santa Margarita to Spokane (Washington) | 969.78 mi (1,560.72 km) |
| Rancho Santa Margarita to Spokane Valley (Washington) | 969.62 mi (1,560.45 km) |
