| Rancho Santa Margarita to South Plainfield (New Jersey) | 2,402.81 mi (3,866.94 km) |
| Rancho Santa Margarita to South Portland (Maine) | 2,607.67 mi (4,196.64 km) |
| Rancho Santa Margarita to South Riding (Virginia) | 2,244.28 mi (3,611.81 km) |
| Rancho Santa Margarita to South River (New Jersey) | 2,405.16 mi (3,870.74 km) |
| Rancho Santa Margarita to South Salt Lake (Utah) | 580.53 mi (934.27 km) |
| Rancho Santa Margarita to South San Francisco (California) | 387.82 mi (624.14 km) |
| Rancho Santa Margarita to South San Jose Hills (California) | 31.60 mi (50.86 km) |
| Rancho Santa Margarita to South Sioux City (Nebraska) | 1,299.19 mi (2,090.85 km) |
| Rancho Santa Margarita to South St. Paul (Minnesota) | 1,517.72 mi (2,442.53 km) |
| Rancho Santa Margarita to South Valley (New Mexico) | 629.86 mi (1,013.66 km) |
| Rancho Santa Margarita to South Venice (Florida) | 2,136.08 mi (3,437.69 km) |
| Rancho Santa Margarita to South Whittier (California) | 32.43 mi (52.18 km) |
| Rancho Santa Margarita to South Yarmouth (Massachusetts) | 2,617.76 mi (4,212.87 km) |
| Rancho Santa Margarita to Southaven (Mississippi) | 1,574.30 mi (2,533.59 km) |
| Rancho Santa Margarita to Southchase (Florida) | 2,163.64 mi (3,482.04 km) |
