| Rancho Santa Margarita to South Fulton (Georgia) | 1,891.32 mi (3,043.78 km) |
| Rancho Santa Margarita to South Gate (California) | 40.37 mi (64.98 km) |
| Rancho Santa Margarita to South Hill (Washington) | 963.55 mi (1,550.69 km) |
| Rancho Santa Margarita to South Holland (Illinois) | 1,721.31 mi (2,770.18 km) |
| Rancho Santa Margarita to South Houston (Texas) | 1,341.27 mi (2,158.57 km) |
| Rancho Santa Margarita to South Huntington (New York) | 2,455.53 mi (3,951.79 km) |
| Rancho Santa Margarita to South Jordan (Utah) | 569.69 mi (916.83 km) |
| Rancho Santa Margarita to South Lake Tahoe (California) | 389.97 mi (627.59 km) |
| Rancho Santa Margarita to South Laurel (Maryland) | 2,279.47 mi (3,668.45 km) |
| Rancho Santa Margarita to South Lyon (Michigan) | 1,930.30 mi (3,106.52 km) |
| Rancho Santa Margarita to South Miami (Florida) | 2,292.28 mi (3,689.07 km) |
| Rancho Santa Margarita to South Miami Heights (Florida) | 2,290.26 mi (3,685.82 km) |
| Rancho Santa Margarita to South Milwaukee (Wisconsin) | 1,724.48 mi (2,775.29 km) |
| Rancho Santa Margarita to South Ogden (Utah) | 605.72 mi (974.81 km) |
| Rancho Santa Margarita to South Pasadena (California) | 46.04 mi (74.09 km) |
