| Rancho Santa Margarita to Somersworth (New Hampshire) | 2,578.27 mi (4,149.33 km) |
| Rancho Santa Margarita to Somerton (Arizona) | 182.28 mi (293.35 km) |
| Rancho Santa Margarita to Somerville (Massachusetts) | 2,569.06 mi (4,134.50 km) |
| Rancho Santa Margarita to Somerville (New Jersey) | 2,392.65 mi (3,850.60 km) |
| Rancho Santa Margarita to Sonoma (California) | 421.17 mi (677.80 km) |
| Rancho Santa Margarita to Soquel (California) | 337.89 mi (543.78 km) |
| Rancho Santa Margarita to South Bend (Indiana) | 1,790.19 mi (2,881.03 km) |
| Rancho Santa Margarita to South Bradenton (Florida) | 2,116.34 mi (3,405.93 km) |
| Rancho Santa Margarita to South Burlington (Vermont) | 2,462.66 mi (3,963.26 km) |
| Rancho Santa Margarita to South Charleston (West Virginia) | 2,019.45 mi (3,249.99 km) |
| Rancho Santa Margarita to South Daytona (Florida) | 2,168.76 mi (3,490.27 km) |
| Rancho Santa Margarita to South El Monte (California) | 38.70 mi (62.28 km) |
| Rancho Santa Margarita to South Elgin (Illinois) | 1,689.69 mi (2,719.29 km) |
| Rancho Santa Margarita to South Euclid (Ohio) | 2,033.05 mi (3,271.89 km) |
| Rancho Santa Margarita to South Farmingdale (New York) | 2,453.01 mi (3,947.74 km) |
