| Rancho Santa Margarita to Smyrna (Delaware) | 2,344.60 mi (3,773.26 km) |
| Rancho Santa Margarita to Smyrna (Georgia) | 1,892.32 mi (3,045.39 km) |
| Rancho Santa Margarita to Smyrna (Tennessee) | 1,762.85 mi (2,837.04 km) |
| Rancho Santa Margarita to Snellville (Georgia) | 1,921.47 mi (3,092.30 km) |
| Rancho Santa Margarita to Snoqualmie (Washington) | 985.29 mi (1,585.68 km) |
| Rancho Santa Margarita to Snyder (Texas) | 966.11 mi (1,554.80 km) |
| Rancho Santa Margarita to Socastee (South Carolina) | 2,206.03 mi (3,550.26 km) |
| Rancho Santa Margarita to Socorro (Texas) | 673.59 mi (1,084.03 km) |
| Rancho Santa Margarita to Soddy-Daisy (Tennessee) | 1,842.78 mi (2,965.66 km) |
| Rancho Santa Margarita to Solana Beach (California) | 48.26 mi (77.66 km) |
| Rancho Santa Margarita to Soledad (California) | 287.34 mi (462.42 km) |
| Rancho Santa Margarita to Solon (Ohio) | 2,036.84 mi (3,277.98 km) |
| Rancho Santa Margarita to Somers Point (New Jersey) | 2,397.90 mi (3,859.05 km) |
| Rancho Santa Margarita to Somerset (Kentucky) | 1,864.67 mi (3,000.90 km) |
| Rancho Santa Margarita to Somerset (New Jersey) | 2,398.52 mi (3,860.04 km) |
