| Rancho Santa Margarita to Shoreview (Minnesota) | 1,518.66 mi (2,444.05 km) |
| Rancho Santa Margarita to Shorewood (Illinois) | 1,689.16 mi (2,718.44 km) |
| Rancho Santa Margarita to Shorewood (Wisconsin) | 1,725.90 mi (2,777.56 km) |
| Rancho Santa Margarita to Short Hills (New Jersey) | 2,406.89 mi (3,873.51 km) |
| Rancho Santa Margarita to Short Pump (Virginia) | 2,244.93 mi (3,612.86 km) |
| Rancho Santa Margarita to Show Low (Arizona) | 435.44 mi (700.77 km) |
| Rancho Santa Margarita to Shreveport (Louisiana) | 1,377.88 mi (2,217.49 km) |
| Rancho Santa Margarita to Sicklerville (New Jersey) | 2,375.34 mi (3,822.74 km) |
| Rancho Santa Margarita to Sidney (Ohio) | 1,890.09 mi (3,041.81 km) |
| Rancho Santa Margarita to Sierra Madre (California) | 45.24 mi (72.81 km) |
| Rancho Santa Margarita to Sierra Vista (Arizona) | 447.29 mi (719.84 km) |
| Rancho Santa Margarita to Sierra Vista Southeast (Arizona) | 455.48 mi (733.02 km) |
| Rancho Santa Margarita to Signal Hill (California) | 34.79 mi (55.99 km) |
| Rancho Santa Margarita to Sikeston (Missouri) | 1,590.45 mi (2,559.59 km) |
| Rancho Santa Margarita to Siloam Springs (Arkansas) | 1,315.71 mi (2,117.43 km) |
