| Rancho Santa Margarita to Seymour (Tennessee) | 1,917.25 mi (3,085.51 km) |
| Rancho Santa Margarita to Shady Hills (Florida) | 2,096.55 mi (3,374.07 km) |
| Rancho Santa Margarita to Shafter (California) | 156.87 mi (252.47 km) |
| Rancho Santa Margarita to Shaker Heights (Ohio) | 2,031.54 mi (3,269.45 km) |
| Rancho Santa Margarita to Shakopee (Minnesota) | 1,494.98 mi (2,405.94 km) |
| Rancho Santa Margarita to Sharon (Pennsylvania) | 2,085.04 mi (3,355.55 km) |
| Rancho Santa Margarita to Sharonville (Ohio) | 1,874.35 mi (3,016.48 km) |
| Rancho Santa Margarita to Shasta Lake (California) | 553.25 mi (890.36 km) |
| Rancho Santa Margarita to Shawnee (Kansas) | 1,318.11 mi (2,121.30 km) |
| Rancho Santa Margarita to Shawnee (Oklahoma) | 1,178.90 mi (1,897.25 km) |
| Rancho Santa Margarita to Sheboygan (Wisconsin) | 1,743.44 mi (2,805.80 km) |
| Rancho Santa Margarita to Shelby (North Carolina) | 2,045.82 mi (3,292.43 km) |
| Rancho Santa Margarita to Shelbyville (Indiana) | 1,801.86 mi (2,899.81 km) |
| Rancho Santa Margarita to Shelbyville (Kentucky) | 1,829.05 mi (2,943.58 km) |
| Rancho Santa Margarita to Shelbyville (Tennessee) | 1,769.53 mi (2,847.79 km) |
