| Rancho Santa Margarita to Security-Widefield (Colorado) | 799.72 mi (1,287.03 km) |
| Rancho Santa Margarita to Sedalia (Missouri) | 1,398.89 mi (2,251.29 km) |
| Rancho Santa Margarita to Sedro-Woolley (Washington) | 1,055.50 mi (1,698.66 km) |
| Rancho Santa Margarita to Seguin (Texas) | 1,186.41 mi (1,909.34 km) |
| Rancho Santa Margarita to Selden (New York) | 2,473.39 mi (3,980.53 km) |
| Rancho Santa Margarita to Selma (Alabama) | 1,766.23 mi (2,842.47 km) |
| Rancho Santa Margarita to Selma (California) | 232.87 mi (374.77 km) |
| Rancho Santa Margarita to Selma (Texas) | 1,166.80 mi (1,877.78 km) |
| Rancho Santa Margarita to Seminole (Florida) | 2,095.69 mi (3,372.69 km) |
| Rancho Santa Margarita to Seven Hills (Ohio) | 2,024.73 mi (3,258.48 km) |
| Rancho Santa Margarita to Seven Oaks (South Carolina) | 2,081.08 mi (3,349.17 km) |
| Rancho Santa Margarita to Severn (Maryland) | 2,287.19 mi (3,680.87 km) |
| Rancho Santa Margarita to Severna Park (Maryland) | 2,294.18 mi (3,692.13 km) |
| Rancho Santa Margarita to Sevierville (Tennessee) | 1,928.29 mi (3,103.28 km) |
| Rancho Santa Margarita to Seymour (Indiana) | 1,794.14 mi (2,887.38 km) |
