| Rancho Santa Margarita to Scottsboro (Alabama) | 1,798.24 mi (2,893.99 km) |
| Rancho Santa Margarita to Scottsdale (Arizona) | 329.72 mi (530.64 km) |
| Rancho Santa Margarita to Scranton (Pennsylvania) | 2,336.06 mi (3,759.52 km) |
| Rancho Santa Margarita to Seabrook (Maryland) | 2,279.56 mi (3,668.60 km) |
| Rancho Santa Margarita to Seabrook (Texas) | 1,354.81 mi (2,180.35 km) |
| Rancho Santa Margarita to Seaford (New York) | 2,450.84 mi (3,944.25 km) |
| Rancho Santa Margarita to Seagoville (Texas) | 1,217.77 mi (1,959.80 km) |
| Rancho Santa Margarita to Seal Beach (California) | 28.45 mi (45.79 km) |
| Rancho Santa Margarita to Searcy (Arkansas) | 1,473.87 mi (2,371.96 km) |
| Rancho Santa Margarita to Seaside (California) | 315.52 mi (507.78 km) |
| Rancho Santa Margarita to SeaTac (Washington) | 985.26 mi (1,585.63 km) |
| Rancho Santa Margarita to Seattle (Washington) | 997.33 mi (1,605.05 km) |
| Rancho Santa Margarita to Sebastian (Florida) | 2,229.54 mi (3,588.10 km) |
| Rancho Santa Margarita to Sebring (Florida) | 2,180.90 mi (3,509.81 km) |
| Rancho Santa Margarita to Secaucus (New Jersey) | 2,420.46 mi (3,895.35 km) |
