| Rancho Santa Margarita to Savannah (Georgia) | 2,106.28 mi (3,389.73 km) |
| Rancho Santa Margarita to Sayreville (New Jersey) | 2,407.96 mi (3,875.24 km) |
| Rancho Santa Margarita to Sayville (New York) | 2,471.89 mi (3,978.13 km) |
| Rancho Santa Margarita to Scaggsville (Maryland) | 2,277.07 mi (3,664.59 km) |
| Rancho Santa Margarita to Scarsdale (New York) | 2,434.90 mi (3,918.60 km) |
| Rancho Santa Margarita to Schaumburg (Illinois) | 1,701.79 mi (2,738.76 km) |
| Rancho Santa Margarita to Schenectady (New York) | 2,424.88 mi (3,902.46 km) |
| Rancho Santa Margarita to Schererville (Indiana) | 1,728.23 mi (2,781.32 km) |
| Rancho Santa Margarita to Schertz (Texas) | 1,170.68 mi (1,884.02 km) |
| Rancho Santa Margarita to Schiller Park (Illinois) | 1,711.77 mi (2,754.82 km) |
| Rancho Santa Margarita to Schofield Barracks (Hawaii) | 2,597.50 mi (4,180.27 km) |
| Rancho Santa Margarita to Scotchtown (New York) | 2,403.20 mi (3,867.58 km) |
| Rancho Santa Margarita to Scottdale (Georgia) | 1,907.42 mi (3,069.70 km) |
| Rancho Santa Margarita to Scotts Valley (California) | 343.16 mi (552.27 km) |
| Rancho Santa Margarita to Scottsbluff (Nebraska) | 948.54 mi (1,526.53 km) |
