| Rancho Santa Margarita to Sanford (Maine) | 2,584.50 mi (4,159.35 km) |
| Rancho Santa Margarita to Sanford (North Carolina) | 2,176.21 mi (3,502.27 km) |
| Rancho Santa Margarita to Sanger (California) | 239.05 mi (384.71 km) |
| Rancho Santa Margarita to Santa Ana (California) | 17.82 mi (28.67 km) |
| Rancho Santa Margarita to Santa Barbara (California) | 133.36 mi (214.62 km) |
| Rancho Santa Margarita to Santa Clara (California) | 356.17 mi (573.20 km) |
| Rancho Santa Margarita to Santa Clara (Oregon) | 782.68 mi (1,259.60 km) |
| Rancho Santa Margarita to Santa Clarita (California) | 74.76 mi (120.31 km) |
| Rancho Santa Margarita to Santa Cruz (California) | 340.57 mi (548.09 km) |
| Rancho Santa Margarita to Santa Fe (New Mexico) | 674.61 mi (1,085.68 km) |
| Rancho Santa Margarita to Santa Fe (Texas) | 1,354.39 mi (2,179.68 km) |
| Rancho Santa Margarita to Santa Fe Springs (California) | 33.79 mi (54.38 km) |
| Rancho Santa Margarita to Santa Maria (California) | 185.61 mi (298.70 km) |
| Rancho Santa Margarita to Santa Monica (California) | 57.41 mi (92.40 km) |
| Rancho Santa Margarita to Santa Paula (California) | 97.74 mi (157.30 km) |
