| Rancho Santa Margarita to San Luis Obispo (California) | 208.22 mi (335.10 km) |
| Rancho Santa Margarita to San Marcos (California) | 42.17 mi (67.86 km) |
| Rancho Santa Margarita to San Marcos (Texas) | 1,182.10 mi (1,902.40 km) |
| Rancho Santa Margarita to San Marino (California) | 44.94 mi (72.33 km) |
| Rancho Santa Margarita to San Mateo (California) | 378.71 mi (609.47 km) |
| Rancho Santa Margarita to San Pablo (California) | 400.16 mi (643.99 km) |
| Rancho Santa Margarita to San Rafael (California) | 408.27 mi (657.04 km) |
| Rancho Santa Margarita to San Ramon (California) | 374.99 mi (603.49 km) |
| Rancho Santa Margarita to San Tan Valley (Arizona) | 349.50 mi (562.46 km) |
| Rancho Santa Margarita to Sand Springs (Oklahoma) | 1,226.58 mi (1,973.99 km) |
| Rancho Santa Margarita to Sandusky (Ohio) | 1,971.86 mi (3,173.41 km) |
| Rancho Santa Margarita to Sandy (Oregon) | 849.89 mi (1,367.76 km) |
| Rancho Santa Margarita to Sandy (Utah) | 574.32 mi (924.28 km) |
| Rancho Santa Margarita to Sandy Springs (Georgia) | 1,899.84 mi (3,057.50 km) |
| Rancho Santa Margarita to Sanford (Florida) | 2,161.23 mi (3,478.16 km) |
