| Rancho Santa Margarita to San Diego (California) | 61.79 mi (99.44 km) |
| Rancho Santa Margarita to San Diego Country Estates (California) | 63.59 mi (102.34 km) |
| Rancho Santa Margarita to San Dimas (California) | 35.06 mi (56.42 km) |
| Rancho Santa Margarita to San Fernando (California) | 66.05 mi (106.29 km) |
| Rancho Santa Margarita to San Francisco (California) | 393.75 mi (633.69 km) |
| Rancho Santa Margarita to San Gabriel (California) | 42.98 mi (69.17 km) |
| Rancho Santa Margarita to San Germán (Puerto Rico) | 3,286.19 mi (5,288.61 km) |
| Rancho Santa Margarita to San Jacinto (California) | 36.72 mi (59.09 km) |
| Rancho Santa Margarita to San Jose (California) | 348.42 mi (560.73 km) |
| Rancho Santa Margarita to San Juan (Puerto Rico) | 3,331.95 mi (5,362.25 km) |
| Rancho Santa Margarita to San Juan (Texas) | 1,270.33 mi (2,044.40 km) |
| Rancho Santa Margarita to San Juan Capistrano (California) | 9.60 mi (15.45 km) |
| Rancho Santa Margarita to San Leandro (California) | 380.47 mi (612.31 km) |
| Rancho Santa Margarita to San Lorenzo (California) | 377.76 mi (607.95 km) |
| Rancho Santa Margarita to San Luis (Arizona) | 184.96 mi (297.67 km) |
