| Rancho Santa Margarita to Salisbury (New York) | 2,447.00 mi (3,938.06 km) |
| Rancho Santa Margarita to Salisbury (North Carolina) | 2,101.42 mi (3,381.91 km) |
| Rancho Santa Margarita to Salmon Creek (Washington) | 876.42 mi (1,410.47 km) |
| Rancho Santa Margarita to Salt Lake City (Utah) | 583.67 mi (939.33 km) |
| Rancho Santa Margarita to Sammamish (Washington) | 992.51 mi (1,597.29 km) |
| Rancho Santa Margarita to San Angelo (Texas) | 1,009.05 mi (1,623.92 km) |
| Rancho Santa Margarita to San Anselmo (California) | 409.66 mi (659.29 km) |
| Rancho Santa Margarita to San Antonio (Texas) | 1,157.61 mi (1,863.00 km) |
| Rancho Santa Margarita to San Benito (Texas) | 1,300.04 mi (2,092.21 km) |
| Rancho Santa Margarita to San Bernardino (California) | 39.32 mi (63.27 km) |
| Rancho Santa Margarita to San Bruno (California) | 386.92 mi (622.69 km) |
| Rancho Santa Margarita to San Buenaventura (California) | 103.56 mi (166.66 km) |
| Rancho Santa Margarita to San Carlos (California) | 374.36 mi (602.48 km) |
| Rancho Santa Margarita to San Carlos Park (Florida) | 2,184.64 mi (3,515.83 km) |
| Rancho Santa Margarita to San Clemente (California) | 12.59 mi (20.25 km) |
