| Rancho Santa Margarita to Saddlebrooke (Arizona) | 396.19 mi (637.61 km) |
| Rancho Santa Margarita to Safety Harbor (Florida) | 2,096.92 mi (3,374.67 km) |
| Rancho Santa Margarita to Saginaw (Michigan) | 1,924.73 mi (3,097.56 km) |
| Rancho Santa Margarita to Saginaw (Texas) | 1,168.48 mi (1,880.48 km) |
| Rancho Santa Margarita to Sahuarita (Arizona) | 402.73 mi (648.14 km) |
| Rancho Santa Margarita to Saks (Alabama) | 1,818.08 mi (2,925.91 km) |
| Rancho Santa Margarita to Salem (Massachusetts) | 2,578.90 mi (4,150.33 km) |
| Rancho Santa Margarita to Salem (Ohio) | 2,065.96 mi (3,324.84 km) |
| Rancho Santa Margarita to Salem (Oregon) | 831.88 mi (1,338.78 km) |
| Rancho Santa Margarita to Salem (Virginia) | 2,114.04 mi (3,402.21 km) |
| Rancho Santa Margarita to Salem Lakes (Wisconsin) | 1,705.96 mi (2,745.47 km) |
| Rancho Santa Margarita to Salida (California) | 342.87 mi (551.80 km) |
| Rancho Santa Margarita to Salina (Kansas) | 1,167.21 mi (1,878.44 km) |
| Rancho Santa Margarita to Salinas (California) | 310.57 mi (499.82 km) |
| Rancho Santa Margarita to Salisbury (Maryland) | 2,350.69 mi (3,783.08 km) |
