| Rancho Santa Margarita to Roy (Utah) | 603.15 mi (970.67 km) |
| Rancho Santa Margarita to Royal Kunia (Hawaii) | 2,598.64 mi (4,182.10 km) |
| Rancho Santa Margarita to Royal Oak (Michigan) | 1,955.92 mi (3,147.74 km) |
| Rancho Santa Margarita to Royal Palm Beach (Florida) | 2,270.53 mi (3,654.07 km) |
| Rancho Santa Margarita to Royse City (Texas) | 1,227.58 mi (1,975.60 km) |
| Rancho Santa Margarita to Ruskin (Florida) | 2,119.79 mi (3,411.47 km) |
| Rancho Santa Margarita to Russellville (Alabama) | 1,704.47 mi (2,743.08 km) |
| Rancho Santa Margarita to Russellville (Arkansas) | 1,394.68 mi (2,244.52 km) |
| Rancho Santa Margarita to Ruston (Louisiana) | 1,443.64 mi (2,323.31 km) |
| Rancho Santa Margarita to Rutherford (New Jersey) | 2,418.26 mi (3,891.82 km) |
| Rancho Santa Margarita to Rutland (Vermont) | 2,473.19 mi (3,980.21 km) |
| Rancho Santa Margarita to Sabana Grande (Puerto Rico) | 3,290.83 mi (5,296.09 km) |
| Rancho Santa Margarita to Sachse (Texas) | 1,212.59 mi (1,951.47 km) |
| Rancho Santa Margarita to Saco (Maine) | 2,599.13 mi (4,182.90 km) |
| Rancho Santa Margarita to Sacramento (California) | 403.60 mi (649.54 km) |
