| Rancho Santa Margarita to Romeoville (Illinois) | 1,696.30 mi (2,729.93 km) |
| Rancho Santa Margarita to Romulus (Michigan) | 1,942.91 mi (3,126.81 km) |
| Rancho Santa Margarita to Ronkonkoma (New York) | 2,469.56 mi (3,974.38 km) |
| Rancho Santa Margarita to Roosevelt (New York) | 2,446.01 mi (3,936.47 km) |
| Rancho Santa Margarita to Rosamond (California) | 92.25 mi (148.46 km) |
| Rancho Santa Margarita to Rosaryville (Maryland) | 2,281.78 mi (3,672.17 km) |
| Rancho Santa Margarita to Roscoe (Illinois) | 1,660.60 mi (2,672.48 km) |
| Rancho Santa Margarita to Rose Hill (Virginia) | 2,266.54 mi (3,647.64 km) |
| Rancho Santa Margarita to Roseburg (Oregon) | 731.75 mi (1,177.63 km) |
| Rancho Santa Margarita to Rosedale (California) | 152.00 mi (244.62 km) |
| Rancho Santa Margarita to Rosedale (Maryland) | 2,296.43 mi (3,695.74 km) |
| Rancho Santa Margarita to Roselle (Illinois) | 1,701.06 mi (2,737.60 km) |
| Rancho Santa Margarita to Roselle (New Jersey) | 2,410.70 mi (3,879.65 km) |
| Rancho Santa Margarita to Roselle Park (New Jersey) | 2,410.31 mi (3,879.02 km) |
| Rancho Santa Margarita to Rosemead (California) | 41.01 mi (66.00 km) |
