| Rancho Santa Margarita to Reidsville (North Carolina) | 2,141.38 mi (3,446.22 km) |
| Rancho Santa Margarita to Reisterstown (Maryland) | 2,279.66 mi (3,668.76 km) |
| Rancho Santa Margarita to Rendon (Texas) | 1,178.95 mi (1,897.33 km) |
| Rancho Santa Margarita to Reno (Nevada) | 427.46 mi (687.94 km) |
| Rancho Santa Margarita to Renton (Washington) | 986.16 mi (1,587.06 km) |
| Rancho Santa Margarita to Republic (Missouri) | 1,378.15 mi (2,217.92 km) |
| Rancho Santa Margarita to Reston (Virginia) | 2,253.09 mi (3,626.00 km) |
| Rancho Santa Margarita to Revere (Massachusetts) | 2,573.95 mi (4,142.37 km) |
| Rancho Santa Margarita to Rexburg (Idaho) | 770.04 mi (1,239.26 km) |
| Rancho Santa Margarita to Reynoldsburg (Ohio) | 1,961.51 mi (3,156.75 km) |
| Rancho Santa Margarita to Rialto (California) | 35.65 mi (57.37 km) |
| Rancho Santa Margarita to Richardson (Texas) | 1,205.13 mi (1,939.48 km) |
| Rancho Santa Margarita to Richfield (Minnesota) | 1,506.48 mi (2,424.44 km) |
| Rancho Santa Margarita to Richfield (Wisconsin) | 1,710.64 mi (2,753.01 km) |
| Rancho Santa Margarita to Richland (Washington) | 878.61 mi (1,413.99 km) |
