| Rancho Santa Margarita to Pullman (Washington) | 905.53 mi (1,457.31 km) |
| Rancho Santa Margarita to Punta Gorda (Florida) | 2,160.74 mi (3,477.38 km) |
| Rancho Santa Margarita to Puyallup (Washington) | 967.56 mi (1,557.14 km) |
| Rancho Santa Margarita to Queen Creek (Arizona) | 345.86 mi (556.60 km) |
| Rancho Santa Margarita to Queens (New York) | 2,434.58 mi (3,918.08 km) |
| Rancho Santa Margarita to Quincy (Illinois) | 1,508.53 mi (2,427.75 km) |
| Rancho Santa Margarita to Quincy (Massachusetts) | 2,573.66 mi (4,141.91 km) |
| Rancho Santa Margarita to Raceland (Louisiana) | 1,603.44 mi (2,580.48 km) |
| Rancho Santa Margarita to Racine (Wisconsin) | 1,724.36 mi (2,775.08 km) |
| Rancho Santa Margarita to Radcliff (Kentucky) | 1,790.65 mi (2,881.77 km) |
| Rancho Santa Margarita to Radford (Virginia) | 2,087.34 mi (3,359.25 km) |
| Rancho Santa Margarita to Rahway (New Jersey) | 2,409.75 mi (3,878.12 km) |
| Rancho Santa Margarita to Raleigh (North Carolina) | 2,202.69 mi (3,544.89 km) |
| Rancho Santa Margarita to Ramona (California) | 58.04 mi (93.40 km) |
| Rancho Santa Margarita to Ramsey (Minnesota) | 1,509.49 mi (2,429.29 km) |
