| Rancho Santa Margarita to Owosso (Michigan) | 1,908.99 mi (3,072.22 km) |
| Rancho Santa Margarita to Oxford (Alabama) | 1,818.45 mi (2,926.51 km) |
| Rancho Santa Margarita to Oxford (Mississippi) | 1,603.32 mi (2,580.29 km) |
| Rancho Santa Margarita to Oxford (Ohio) | 1,856.86 mi (2,988.32 km) |
| Rancho Santa Margarita to Oxnard (California) | 98.78 mi (158.97 km) |
| Rancho Santa Margarita to Oxon Hill (Maryland) | 2,273.83 mi (3,659.38 km) |
| Rancho Santa Margarita to Ozark (Alabama) | 1,859.78 mi (2,993.03 km) |
| Rancho Santa Margarita to Ozark (Missouri) | 1,390.40 mi (2,237.62 km) |
| Rancho Santa Margarita to Pace (Florida) | 1,786.40 mi (2,874.93 km) |
| Rancho Santa Margarita to Pacific Grove (California) | 319.91 mi (514.85 km) |
| Rancho Santa Margarita to Pacifica (California) | 388.09 mi (624.57 km) |
| Rancho Santa Margarita to Paducah (Kentucky) | 1,642.47 mi (2,643.30 km) |
| Rancho Santa Margarita to Pahrump (Nevada) | 200.73 mi (323.04 km) |
| Rancho Santa Margarita to Painesville (Ohio) | 2,047.92 mi (3,295.81 km) |
| Rancho Santa Margarita to Palatine (Illinois) | 1,704.92 mi (2,743.80 km) |
