| Rancho Santa Margarita to Orangeburg (South Carolina) | 2,103.45 mi (3,385.18 km) |
| Rancho Santa Margarita to Orangevale (California) | 403.49 mi (649.35 km) |
| Rancho Santa Margarita to Orchards (Washington) | 872.94 mi (1,404.86 km) |
| Rancho Santa Margarita to Orcutt (California) | 182.50 mi (293.70 km) |
| Rancho Santa Margarita to Oregon (Ohio) | 1,935.48 mi (3,114.86 km) |
| Rancho Santa Margarita to Oregon (Wisconsin) | 1,649.32 mi (2,654.33 km) |
| Rancho Santa Margarita to Oregon City (Oregon) | 851.32 mi (1,370.07 km) |
| Rancho Santa Margarita to Orem (Utah) | 563.79 mi (907.33 km) |
| Rancho Santa Margarita to Orinda (California) | 389.94 mi (627.54 km) |
| Rancho Santa Margarita to Orland Park (Illinois) | 1,708.16 mi (2,749.01 km) |
| Rancho Santa Margarita to Orlando (Florida) | 2,164.52 mi (3,483.46 km) |
| Rancho Santa Margarita to Ormond Beach (Florida) | 2,160.48 mi (3,476.95 km) |
| Rancho Santa Margarita to Oro Valley (Arizona) | 392.55 mi (631.76 km) |
| Rancho Santa Margarita to Oroville (California) | 461.16 mi (742.17 km) |
| Rancho Santa Margarita to Oshkosh (Wisconsin) | 1,708.13 mi (2,748.96 km) |
