| Rancho Santa Margarita to Odenton (Maryland) | 2,287.57 mi (3,681.49 km) |
| Rancho Santa Margarita to Odessa (Texas) | 893.74 mi (1,438.33 km) |
| Rancho Santa Margarita to Ogden (Utah) | 608.67 mi (979.56 km) |
| Rancho Santa Margarita to Oildale (California) | 148.54 mi (239.06 km) |
| Rancho Santa Margarita to Ojus (Florida) | 2,293.42 mi (3,690.90 km) |
| Rancho Santa Margarita to Okemos (Michigan) | 1,894.18 mi (3,048.38 km) |
| Rancho Santa Margarita to Oklahoma City (Oklahoma) | 1,148.01 mi (1,847.55 km) |
| Rancho Santa Margarita to Okmulgee (Oklahoma) | 1,232.78 mi (1,983.97 km) |
| Rancho Santa Margarita to Olathe (Kansas) | 1,316.00 mi (2,117.90 km) |
| Rancho Santa Margarita to Old Jamestown (Missouri) | 1,557.86 mi (2,507.13 km) |
| Rancho Santa Margarita to Oldsmar (Florida) | 2,097.47 mi (3,375.55 km) |
| Rancho Santa Margarita to Olean (New York) | 2,194.13 mi (3,531.11 km) |
| Rancho Santa Margarita to Olive Branch (Mississippi) | 1,581.68 mi (2,545.47 km) |
| Rancho Santa Margarita to Olivehurst (California) | 435.98 mi (701.64 km) |
| Rancho Santa Margarita to Olney (Maryland) | 2,267.03 mi (3,648.44 km) |
