| Rancho Santa Margarita to Oakleaf Plantation (Florida) | 2,101.11 mi (3,381.41 km) |
| Rancho Santa Margarita to Oakley (California) | 378.69 mi (609.44 km) |
| Rancho Santa Margarita to Oakton (Virginia) | 2,255.73 mi (3,630.25 km) |
| Rancho Santa Margarita to Oakville (Missouri) | 1,553.88 mi (2,500.73 km) |
| Rancho Santa Margarita to Oatfield (Oregon) | 855.94 mi (1,377.51 km) |
| Rancho Santa Margarita to Ocala (Florida) | 2,102.62 mi (3,383.84 km) |
| Rancho Santa Margarita to Ocean Acres (New Jersey) | 2,413.14 mi (3,883.58 km) |
| Rancho Santa Margarita to Ocean City (New Jersey) | 2,398.40 mi (3,859.86 km) |
| Rancho Santa Margarita to Ocean Pines (Maryland) | 2,374.25 mi (3,820.98 km) |
| Rancho Santa Margarita to Ocean Pointe (Hawaii) | 2,601.40 mi (4,186.55 km) |
| Rancho Santa Margarita to Ocean Springs (Mississippi) | 1,697.00 mi (2,731.06 km) |
| Rancho Santa Margarita to Oceanside (California) | 32.74 mi (52.69 km) |
| Rancho Santa Margarita to Oceanside (New York) | 2,443.42 mi (3,932.30 km) |
| Rancho Santa Margarita to Ocoee (Florida) | 2,150.98 mi (3,461.67 km) |
| Rancho Santa Margarita to Oconomowoc (Wisconsin) | 1,696.06 mi (2,729.55 km) |
