| Rancho Santa Margarita to Missouri City (Texas) | 1,325.71 mi (2,133.53 km) |
| Rancho Santa Margarita to Mitchell (South Dakota) | 1,260.03 mi (2,027.83 km) |
| Rancho Santa Margarita to Mitchellville (Maryland) | 2,281.66 mi (3,671.98 km) |
| Rancho Santa Margarita to Moberly (Missouri) | 1,447.79 mi (2,329.99 km) |
| Rancho Santa Margarita to Mobile (Alabama) | 1,730.75 mi (2,785.38 km) |
| Rancho Santa Margarita to Modesto (California) | 336.30 mi (541.22 km) |
| Rancho Santa Margarita to Mokena (Illinois) | 1,706.52 mi (2,746.38 km) |
| Rancho Santa Margarita to Moline (Illinois) | 1,572.77 mi (2,531.13 km) |
| Rancho Santa Margarita to Moncks Corner (South Carolina) | 2,156.21 mi (3,470.08 km) |
| Rancho Santa Margarita to Monfort Heights (Ohio) | 1,863.45 mi (2,998.93 km) |
| Rancho Santa Margarita to Monmouth (Oregon) | 831.08 mi (1,337.49 km) |
| Rancho Santa Margarita to Monroe (Georgia) | 1,938.40 mi (3,119.55 km) |
| Rancho Santa Margarita to Monroe (Louisiana) | 1,475.88 mi (2,375.20 km) |
| Rancho Santa Margarita to Monroe (Michigan) | 1,939.68 mi (3,121.61 km) |
| Rancho Santa Margarita to Monroe (North Carolina) | 2,103.64 mi (3,385.48 km) |
