| Rancho Santa Margarita to Mineola (New York) | 2,442.86 mi (3,931.41 km) |
| Rancho Santa Margarita to Mineral Wells (Texas) | 1,128.03 mi (1,815.39 km) |
| Rancho Santa Margarita to Minneapolis (Minnesota) | 1,509.48 mi (2,429.28 km) |
| Rancho Santa Margarita to Minnehaha (Washington) | 872.33 mi (1,403.88 km) |
| Rancho Santa Margarita to Minneola (Florida) | 2,138.94 mi (3,442.29 km) |
| Rancho Santa Margarita to Minnetonka (Minnesota) | 1,499.99 mi (2,414.01 km) |
| Rancho Santa Margarita to Minooka (Illinois) | 1,685.14 mi (2,711.97 km) |
| Rancho Santa Margarita to Minot (North Dakota) | 1,314.98 mi (2,116.25 km) |
| Rancho Santa Margarita to Mint Hill (North Carolina) | 2,096.76 mi (3,374.41 km) |
| Rancho Santa Margarita to Miramar (Florida) | 2,282.84 mi (3,673.88 km) |
| Rancho Santa Margarita to Mishawaka (Indiana) | 1,795.43 mi (2,889.47 km) |
| Rancho Santa Margarita to Mission (Texas) | 1,260.43 mi (2,028.46 km) |
| Rancho Santa Margarita to Mission Bend (Texas) | 1,315.54 mi (2,117.16 km) |
| Rancho Santa Margarita to Mission Viejo (California) | 3.58 mi (5.77 km) |
| Rancho Santa Margarita to Missoula (Montana) | 934.00 mi (1,503.12 km) |
