| Rancho Santa Margarita to Merriam (Kansas) | 1,324.20 mi (2,131.09 km) |
| Rancho Santa Margarita to Merrick (New York) | 2,447.69 mi (3,939.18 km) |
| Rancho Santa Margarita to Merrifield (Virginia) | 2,258.96 mi (3,635.45 km) |
| Rancho Santa Margarita to Merrillville (Indiana) | 1,734.48 mi (2,791.37 km) |
| Rancho Santa Margarita to Merritt Island (Florida) | 2,206.49 mi (3,551.01 km) |
| Rancho Santa Margarita to Mesa (Arizona) | 339.10 mi (545.73 km) |
| Rancho Santa Margarita to Mesquite (Nevada) | 293.70 mi (472.66 km) |
| Rancho Santa Margarita to Mesquite (Texas) | 1,214.29 mi (1,954.20 km) |
| Rancho Santa Margarita to Metairie (Louisiana) | 1,624.54 mi (2,614.45 km) |
| Rancho Santa Margarita to Methuen Town (Massachusetts) | 2,563.82 mi (4,126.08 km) |
| Rancho Santa Margarita to Metuchen (New Jersey) | 2,405.66 mi (3,871.53 km) |
| Rancho Santa Margarita to Mexico (Missouri) | 1,475.43 mi (2,374.47 km) |
| Rancho Santa Margarita to Miami (Florida) | 2,295.14 mi (3,693.67 km) |
| Rancho Santa Margarita to Miami (Oklahoma) | 1,298.62 mi (2,089.92 km) |
| Rancho Santa Margarita to Miami Beach (Florida) | 2,298.31 mi (3,698.77 km) |
