| Rancho Santa Margarita to Mendota (California) | 266.80 mi (429.37 km) |
| Rancho Santa Margarita to Mendota Heights (Minnesota) | 1,513.08 mi (2,435.06 km) |
| Rancho Santa Margarita to Menifee (California) | 24.15 mi (38.87 km) |
| Rancho Santa Margarita to Menlo Park (California) | 368.99 mi (593.83 km) |
| Rancho Santa Margarita to Menomonee Falls (Wisconsin) | 1,715.11 mi (2,760.21 km) |
| Rancho Santa Margarita to Menomonie (Wisconsin) | 1,569.33 mi (2,525.59 km) |
| Rancho Santa Margarita to Mentor (Ohio) | 2,043.51 mi (3,288.71 km) |
| Rancho Santa Margarita to Mequon (Wisconsin) | 1,723.24 mi (2,773.29 km) |
| Rancho Santa Margarita to Merced (California) | 301.10 mi (484.57 km) |
| Rancho Santa Margarita to Mercedes (Texas) | 1,284.59 mi (2,067.35 km) |
| Rancho Santa Margarita to Mercer Island (Washington) | 992.50 mi (1,597.27 km) |
| Rancho Santa Margarita to Mercerville (New Jersey) | 2,389.40 mi (3,845.37 km) |
| Rancho Santa Margarita to Meriden (Connecticut) | 2,484.38 mi (3,998.22 km) |
| Rancho Santa Margarita to Meridian (Idaho) | 692.56 mi (1,114.56 km) |
| Rancho Santa Margarita to Meridian (Mississippi) | 1,671.82 mi (2,690.53 km) |
