| Rancho Santa Margarita to Medford (Massachusetts) | 2,568.60 mi (4,133.77 km) |
| Rancho Santa Margarita to Medford (New York) | 2,476.74 mi (3,985.92 km) |
| Rancho Santa Margarita to Medford (Oregon) | 665.75 mi (1,071.42 km) |
| Rancho Santa Margarita to Medina (Ohio) | 2,013.57 mi (3,240.53 km) |
| Rancho Santa Margarita to Medulla (Florida) | 2,138.92 mi (3,442.26 km) |
| Rancho Santa Margarita to Mehlville (Missouri) | 1,554.41 mi (2,501.59 km) |
| Rancho Santa Margarita to Melbourne (Florida) | 2,211.60 mi (3,559.23 km) |
| Rancho Santa Margarita to Melissa (Texas) | 1,211.02 mi (1,948.94 km) |
| Rancho Santa Margarita to Melrose (Massachusetts) | 2,571.05 mi (4,137.71 km) |
| Rancho Santa Margarita to Melrose Park (Illinois) | 1,711.40 mi (2,754.24 km) |
| Rancho Santa Margarita to Melville (New York) | 2,454.79 mi (3,950.61 km) |
| Rancho Santa Margarita to Melvindale (Michigan) | 1,952.89 mi (3,142.87 km) |
| Rancho Santa Margarita to Memphis (Florida) | 2,115.60 mi (3,404.74 km) |
| Rancho Santa Margarita to Memphis (Tennessee) | 1,574.15 mi (2,533.35 km) |
| Rancho Santa Margarita to Menasha (Wisconsin) | 1,717.99 mi (2,764.83 km) |
