| Rancho Santa Margarita to McHenry (Illinois) | 1,695.17 mi (2,728.11 km) |
| Rancho Santa Margarita to McKeesport (Pennsylvania) | 2,117.80 mi (3,408.27 km) |
| Rancho Santa Margarita to McKinleyville (California) | 618.23 mi (994.95 km) |
| Rancho Santa Margarita to McKinney (Texas) | 1,205.47 mi (1,940.02 km) |
| Rancho Santa Margarita to McLean (Virginia) | 2,261.26 mi (3,639.15 km) |
| Rancho Santa Margarita to McMinnville (Oregon) | 853.37 mi (1,373.37 km) |
| Rancho Santa Margarita to McMinnville (Tennessee) | 1,805.97 mi (2,906.42 km) |
| Rancho Santa Margarita to McNair (Virginia) | 2,249.58 mi (3,620.35 km) |
| Rancho Santa Margarita to McPherson (Kansas) | 1,158.93 mi (1,865.12 km) |
| Rancho Santa Margarita to Mead Valley (California) | 22.77 mi (36.65 km) |
| Rancho Santa Margarita to Meadow Woods (Florida) | 2,166.36 mi (3,486.42 km) |
| Rancho Santa Margarita to Meadowbrook (Virginia) | 2,254.36 mi (3,628.04 km) |
| Rancho Santa Margarita to Meadville (Pennsylvania) | 2,104.62 mi (3,387.06 km) |
| Rancho Santa Margarita to Mebane (North Carolina) | 2,165.49 mi (3,485.02 km) |
| Rancho Santa Margarita to Mechanicsville (Virginia) | 2,259.49 mi (3,636.30 km) |
