| Rancho Santa Margarita to Malvern (Arkansas) | 1,416.68 mi (2,279.93 km) |
| Rancho Santa Margarita to Manassas (Virginia) | 2,246.53 mi (3,615.45 km) |
| Rancho Santa Margarita to Manassas Park (Virginia) | 2,248.63 mi (3,618.83 km) |
| Rancho Santa Margarita to Manatí (Puerto Rico) | 3,306.80 mi (5,321.79 km) |
| Rancho Santa Margarita to Manchester (Missouri) | 1,544.51 mi (2,485.65 km) |
| Rancho Santa Margarita to Manchester (New Hampshire) | 2,550.45 mi (4,104.56 km) |
| Rancho Santa Margarita to Manchester (Tennessee) | 1,790.73 mi (2,881.90 km) |
| Rancho Santa Margarita to Manchester (Virginia) | 2,250.38 mi (3,621.63 km) |
| Rancho Santa Margarita to Mandan (North Dakota) | 1,263.09 mi (2,032.75 km) |
| Rancho Santa Margarita to Mandeville (Louisiana) | 1,622.57 mi (2,611.27 km) |
| Rancho Santa Margarita to Mango (Florida) | 2,119.70 mi (3,411.33 km) |
| Rancho Santa Margarita to Manhattan (Kansas) | 1,225.55 mi (1,972.32 km) |
| Rancho Santa Margarita to Manhattan (New York) | 2,425.66 mi (3,903.72 km) |
| Rancho Santa Margarita to Manhattan Beach (California) | 49.17 mi (79.13 km) |
| Rancho Santa Margarita to Manitowoc (Wisconsin) | 1,751.78 mi (2,819.22 km) |
