| Rancho Santa Margarita to Madison (Mississippi) | 1,588.12 mi (2,555.83 km) |
| Rancho Santa Margarita to Madison (New Jersey) | 2,402.17 mi (3,865.92 km) |
| Rancho Santa Margarita to Madison (Wisconsin) | 1,651.69 mi (2,658.14 km) |
| Rancho Santa Margarita to Madison Heights (Michigan) | 1,958.46 mi (3,151.84 km) |
| Rancho Santa Margarita to Madison Heights (Virginia) | 2,165.10 mi (3,484.39 km) |
| Rancho Santa Margarita to Madisonville (Kentucky) | 1,705.10 mi (2,744.09 km) |
| Rancho Santa Margarita to Magalia (California) | 481.80 mi (775.38 km) |
| Rancho Santa Margarita to Magna (Utah) | 576.25 mi (927.38 km) |
| Rancho Santa Margarita to Magnolia (Arkansas) | 1,401.94 mi (2,256.21 km) |
| Rancho Santa Margarita to Maili (Hawaii) | 2,606.25 mi (4,194.36 km) |
| Rancho Santa Margarita to Maitland (Florida) | 2,159.17 mi (3,474.85 km) |
| Rancho Santa Margarita to Makakilo (Hawaii) | 2,602.94 mi (4,189.03 km) |
| Rancho Santa Margarita to Malden (Massachusetts) | 2,571.19 mi (4,137.93 km) |
| Rancho Santa Margarita to Malibu (California) | 73.55 mi (118.37 km) |
| Rancho Santa Margarita to Maltby (Washington) | 1,006.68 mi (1,620.10 km) |
