| Rancho Santa Margarita to Los Alamitos (California) | 28.82 mi (46.38 km) |
| Rancho Santa Margarita to Los Alamos (New Mexico) | 660.42 mi (1,062.85 km) |
| Rancho Santa Margarita to Los Altos (California) | 361.37 mi (581.58 km) |
| Rancho Santa Margarita to Los Angeles (California) | 57.09 mi (91.87 km) |
| Rancho Santa Margarita to Los Banos (California) | 299.26 mi (481.60 km) |
| Rancho Santa Margarita to Los Gatos (California) | 349.20 mi (561.98 km) |
| Rancho Santa Margarita to Los Lunas (New Mexico) | 623.11 mi (1,002.80 km) |
| Rancho Santa Margarita to Los Osos (California) | 217.11 mi (349.40 km) |
| Rancho Santa Margarita to Loudoun Valley Estates (Virginia) | 2,244.45 mi (3,612.09 km) |
| Rancho Santa Margarita to Louisville (Colorado) | 815.26 mi (1,312.04 km) |
| Rancho Santa Margarita to Louisville (Kentucky) | 1,806.28 mi (2,906.93 km) |
| Rancho Santa Margarita to Lovejoy (Georgia) | 1,908.33 mi (3,071.16 km) |
| Rancho Santa Margarita to Loveland (Colorado) | 834.14 mi (1,342.42 km) |
| Rancho Santa Margarita to Loveland (Ohio) | 1,881.48 mi (3,027.95 km) |
| Rancho Santa Margarita to Loves Park (Illinois) | 1,659.88 mi (2,671.31 km) |
