| Rancho Santa Margarita to LaGrange (Georgia) | 1,872.33 mi (3,013.22 km) |
| Rancho Santa Margarita to Laguna Beach (California) | 11.09 mi (17.85 km) |
| Rancho Santa Margarita to Laguna Hills (California) | 6.40 mi (10.30 km) |
| Rancho Santa Margarita to Laguna Niguel (California) | 9.45 mi (15.21 km) |
| Rancho Santa Margarita to Laguna Woods (California) | 7.69 mi (12.38 km) |
| Rancho Santa Margarita to Lahaina (Hawaii) | 2,537.85 mi (4,084.27 km) |
| Rancho Santa Margarita to Lake Arbor (Maryland) | 2,280.92 mi (3,670.79 km) |
| Rancho Santa Margarita to Lake Barcroft (Virginia) | 2,263.60 mi (3,642.92 km) |
| Rancho Santa Margarita to Lake Butler (Florida) | 2,152.30 mi (3,463.80 km) |
| Rancho Santa Margarita to Lake Charles (Louisiana) | 1,446.32 mi (2,327.63 km) |
| Rancho Santa Margarita to Lake City (Florida) | 2,053.99 mi (3,305.57 km) |
| Rancho Santa Margarita to Lake Elmo (Minnesota) | 1,526.76 mi (2,457.09 km) |
| Rancho Santa Margarita to Lake Elsinore (California) | 15.64 mi (25.17 km) |
| Rancho Santa Margarita to Lake Forest (California) | 4.62 mi (7.44 km) |
| Rancho Santa Margarita to Lake Forest (Illinois) | 1,715.65 mi (2,761.07 km) |
