| Rancho Santa Margarita to Isabela (Puerto Rico) | 3,273.51 mi (5,268.21 km) |
| Rancho Santa Margarita to Iselin (New Jersey) | 2,407.96 mi (3,875.24 km) |
| Rancho Santa Margarita to Isla Vista (California) | 140.35 mi (225.88 km) |
| Rancho Santa Margarita to Issaquah (Washington) | 988.72 mi (1,591.20 km) |
| Rancho Santa Margarita to Ithaca (New York) | 2,293.55 mi (3,691.12 km) |
| Rancho Santa Margarita to Ives Estates (Florida) | 2,291.95 mi (3,688.54 km) |
| Rancho Santa Margarita to Jackson (Michigan) | 1,890.36 mi (3,042.24 km) |
| Rancho Santa Margarita to Jackson (Mississippi) | 1,585.40 mi (2,551.45 km) |
| Rancho Santa Margarita to Jackson (Missouri) | 1,587.10 mi (2,554.19 km) |
| Rancho Santa Margarita to Jackson (Tennessee) | 1,635.16 mi (2,631.53 km) |
| Rancho Santa Margarita to Jackson (Wyoming) | 772.78 mi (1,243.67 km) |
| Rancho Santa Margarita to Jacksonville (Alabama) | 1,822.69 mi (2,933.33 km) |
| Rancho Santa Margarita to Jacksonville (Arkansas) | 1,453.09 mi (2,338.52 km) |
| Rancho Santa Margarita to Jacksonville (Florida) | 2,107.14 mi (3,391.12 km) |
| Rancho Santa Margarita to Jacksonville (Illinois) | 1,567.01 mi (2,521.86 km) |
