| Rancho Santa Margarita to Indianapolis (Indiana) | 1,783.39 mi (2,870.09 km) |
| Rancho Santa Margarita to Indianola (Iowa) | 1,415.70 mi (2,278.35 km) |
| Rancho Santa Margarita to Indio (California) | 78.75 mi (126.74 km) |
| Rancho Santa Margarita to Inglewood (California) | 48.34 mi (77.79 km) |
| Rancho Santa Margarita to Inkster (Michigan) | 1,946.05 mi (3,131.87 km) |
| Rancho Santa Margarita to Inver Grove Heights (Minnesota) | 1,515.23 mi (2,438.53 km) |
| Rancho Santa Margarita to Inwood (New York) | 2,437.48 mi (3,922.74 km) |
| Rancho Santa Margarita to Iona (Florida) | 2,175.54 mi (3,501.19 km) |
| Rancho Santa Margarita to Ionia (Michigan) | 1,864.02 mi (2,999.85 km) |
| Rancho Santa Margarita to Iowa City (Iowa) | 1,522.80 mi (2,450.70 km) |
| Rancho Santa Margarita to Irmo (South Carolina) | 2,077.51 mi (3,343.43 km) |
| Rancho Santa Margarita to Irondale (Alabama) | 1,773.98 mi (2,854.95 km) |
| Rancho Santa Margarita to Ironton (Ohio) | 1,967.06 mi (3,165.67 km) |
| Rancho Santa Margarita to Irvine (California) | 10.54 mi (16.97 km) |
| Rancho Santa Margarita to Irving (Texas) | 1,191.25 mi (1,917.13 km) |
