| Rancho Santa Margarita to Friendly (Maryland) | 2,274.42 mi (3,660.32 km) |
| Rancho Santa Margarita to Friendswood (Texas) | 1,346.17 mi (2,166.46 km) |
| Rancho Santa Margarita to Frisco (Texas) | 1,197.00 mi (1,926.38 km) |
| Rancho Santa Margarita to Front Royal (Virginia) | 2,208.23 mi (3,553.80 km) |
| Rancho Santa Margarita to Fruit Cove (Florida) | 2,114.89 mi (3,403.59 km) |
| Rancho Santa Margarita to Fruita (Colorado) | 623.08 mi (1,002.76 km) |
| Rancho Santa Margarita to Fruitville (Florida) | 2,126.37 mi (3,422.07 km) |
| Rancho Santa Margarita to Fuller Heights (Florida) | 2,139.07 mi (3,442.50 km) |
| Rancho Santa Margarita to Fullerton (California) | 25.72 mi (41.38 km) |
| Rancho Santa Margarita to Fullerton (Pennsylvania) | 2,346.66 mi (3,776.59 km) |
| Rancho Santa Margarita to Fulshear (Texas) | 1,303.30 mi (2,097.46 km) |
| Rancho Santa Margarita to Fulton (Missouri) | 1,468.72 mi (2,363.68 km) |
| Rancho Santa Margarita to Fulton (New York) | 2,300.22 mi (3,701.85 km) |
| Rancho Santa Margarita to Fuquay-Varina (North Carolina) | 2,197.41 mi (3,536.39 km) |
| Rancho Santa Margarita to Gadsden (Alabama) | 1,805.86 mi (2,906.25 km) |
