| Rancho Santa Margarita to Frederick (Colorado) | 827.91 mi (1,332.39 km) |
| Rancho Santa Margarita to Frederick (Maryland) | 2,247.75 mi (3,617.40 km) |
| Rancho Santa Margarita to Fredericksburg (Texas) | 1,120.40 mi (1,803.10 km) |
| Rancho Santa Margarita to Fredericksburg (Virginia) | 2,248.47 mi (3,618.56 km) |
| Rancho Santa Margarita to Frederickson (Washington) | 962.69 mi (1,549.30 km) |
| Rancho Santa Margarita to Freeport (Illinois) | 1,627.36 mi (2,618.98 km) |
| Rancho Santa Margarita to Freeport (New York) | 2,446.04 mi (3,936.52 km) |
| Rancho Santa Margarita to Freeport (Texas) | 1,349.48 mi (2,171.77 km) |
| Rancho Santa Margarita to Fremont (California) | 364.80 mi (587.08 km) |
| Rancho Santa Margarita to Fremont (Nebraska) | 1,271.82 mi (2,046.80 km) |
| Rancho Santa Margarita to Fremont (Ohio) | 1,950.06 mi (3,138.31 km) |
| Rancho Santa Margarita to French Valley (California) | 28.39 mi (45.69 km) |
| Rancho Santa Margarita to Fresno (California) | 250.50 mi (403.14 km) |
| Rancho Santa Margarita to Fresno (Texas) | 1,330.12 mi (2,140.62 km) |
| Rancho Santa Margarita to Fridley (Minnesota) | 1,513.11 mi (2,435.11 km) |
