| Rancho Santa Margarita to Florence (Kentucky) | 1,861.02 mi (2,995.02 km) |
| Rancho Santa Margarita to Florence (South Carolina) | 2,155.87 mi (3,469.54 km) |
| Rancho Santa Margarita to Florence-Graham (California) | 43.77 mi (70.44 km) |
| Rancho Santa Margarita to Florham Park (New Jersey) | 2,403.25 mi (3,867.66 km) |
| Rancho Santa Margarita to Florida (Puerto Rico) | 3,304.44 mi (5,317.98 km) |
| Rancho Santa Margarita to Florida City (Florida) | 2,289.51 mi (3,684.61 km) |
| Rancho Santa Margarita to Florida Ridge (Florida) | 2,239.87 mi (3,604.73 km) |
| Rancho Santa Margarita to Florin (California) | 396.82 mi (638.62 km) |
| Rancho Santa Margarita to Florissant (Missouri) | 1,555.36 mi (2,503.11 km) |
| Rancho Santa Margarita to Flower Hill (Maryland) | 2,261.02 mi (3,638.76 km) |
| Rancho Santa Margarita to Flower Mound (Texas) | 1,181.28 mi (1,901.08 km) |
| Rancho Santa Margarita to Flowing Wells (Arizona) | 392.85 mi (632.24 km) |
| Rancho Santa Margarita to Foley (Alabama) | 1,761.67 mi (2,835.13 km) |
| Rancho Santa Margarita to Folsom (California) | 400.05 mi (643.81 km) |
| Rancho Santa Margarita to Fond du Lac (Wisconsin) | 1,709.65 mi (2,751.41 km) |
