| Rancho Santa Margarita to Federal Way (Washington) | 976.77 mi (1,571.96 km) |
| Rancho Santa Margarita to Felida (Washington) | 877.44 mi (1,412.10 km) |
| Rancho Santa Margarita to Fenton (Michigan) | 1,930.20 mi (3,106.36 km) |
| Rancho Santa Margarita to Fergus Falls (Minnesota) | 1,428.59 mi (2,299.10 km) |
| Rancho Santa Margarita to Ferguson (Missouri) | 1,556.79 mi (2,505.41 km) |
| Rancho Santa Margarita to Fernandina Beach (Florida) | 2,114.00 mi (3,402.15 km) |
| Rancho Santa Margarita to Ferndale (Maryland) | 2,290.32 mi (3,685.91 km) |
| Rancho Santa Margarita to Ferndale (Michigan) | 1,956.66 mi (3,148.95 km) |
| Rancho Santa Margarita to Ferndale (Washington) | 1,082.53 mi (1,742.16 km) |
| Rancho Santa Margarita to Fernley (Nevada) | 419.17 mi (674.59 km) |
| Rancho Santa Margarita to Ferry Pass (Florida) | 1,786.80 mi (2,875.58 km) |
| Rancho Santa Margarita to Festus (Missouri) | 1,548.00 mi (2,491.27 km) |
| Rancho Santa Margarita to Fife (Washington) | 971.93 mi (1,564.18 km) |
| Rancho Santa Margarita to Fillmore (California) | 92.26 mi (148.48 km) |
| Rancho Santa Margarita to Findlay (Ohio) | 1,921.28 mi (3,092.00 km) |
