| Rancho Santa Margarita to Eugene (Oregon) | 778.61 mi (1,253.06 km) |
| Rancho Santa Margarita to Euless (Texas) | 1,185.02 mi (1,907.10 km) |
| Rancho Santa Margarita to Eureka (California) | 612.04 mi (984.98 km) |
| Rancho Santa Margarita to Eureka (Missouri) | 1,536.38 mi (2,472.57 km) |
| Rancho Santa Margarita to Eustis (Florida) | 2,136.69 mi (3,438.67 km) |
| Rancho Santa Margarita to Evans (Colorado) | 847.18 mi (1,363.41 km) |
| Rancho Santa Margarita to Evans (Georgia) | 2,030.76 mi (3,268.19 km) |
| Rancho Santa Margarita to Evanston (Illinois) | 1,721.66 mi (2,770.74 km) |
| Rancho Santa Margarita to Evanston (Wyoming) | 640.04 mi (1,030.04 km) |
| Rancho Santa Margarita to Evansville (Indiana) | 1,703.61 mi (2,741.70 km) |
| Rancho Santa Margarita to Everett (Massachusetts) | 2,571.41 mi (4,138.28 km) |
| Rancho Santa Margarita to Everett (Washington) | 1,017.43 mi (1,637.39 km) |
| Rancho Santa Margarita to Evergreen Park (Illinois) | 1,717.59 mi (2,764.19 km) |
| Rancho Santa Margarita to Ewa Beach (Hawaii) | 2,600.05 mi (4,184.38 km) |
| Rancho Santa Margarita to Ewa Gentry (Hawaii) | 2,600.60 mi (4,185.27 km) |
