| Rancho Santa Margarita to Enterprise (Nevada) | 212.27 mi (341.62 km) |
| Rancho Santa Margarita to Enumclaw (Washington) | 965.21 mi (1,553.36 km) |
| Rancho Santa Margarita to Ephrata (Pennsylvania) | 2,311.05 mi (3,719.27 km) |
| Rancho Santa Margarita to Erie (Colorado) | 822.40 mi (1,323.52 km) |
| Rancho Santa Margarita to Erie (Pennsylvania) | 2,110.23 mi (3,396.09 km) |
| Rancho Santa Margarita to Erlanger (Kentucky) | 1,864.30 mi (3,000.31 km) |
| Rancho Santa Margarita to Escanaba (Michigan) | 1,810.01 mi (2,912.93 km) |
| Rancho Santa Margarita to Escondido (California) | 45.85 mi (73.78 km) |
| Rancho Santa Margarita to Española (New Mexico) | 673.80 mi (1,084.38 km) |
| Rancho Santa Margarita to Essex (Maryland) | 2,299.91 mi (3,701.35 km) |
| Rancho Santa Margarita to Essex Junction (Vermont) | 2,467.95 mi (3,971.79 km) |
| Rancho Santa Margarita to Estelle (Louisiana) | 1,631.86 mi (2,626.22 km) |
| Rancho Santa Margarita to Estero (Florida) | 2,187.28 mi (3,520.09 km) |
| Rancho Santa Margarita to Euclid (Ohio) | 2,033.65 mi (3,272.84 km) |
| Rancho Santa Margarita to Eufaula (Alabama) | 1,881.19 mi (3,027.49 km) |
