| Rancho Santa Margarita to Elyria (Ohio) | 2,002.33 mi (3,222.45 km) |
| Rancho Santa Margarita to Emeryville (California) | 392.04 mi (630.93 km) |
| Rancho Santa Margarita to Emmaus (Pennsylvania) | 2,346.13 mi (3,775.73 km) |
| Rancho Santa Margarita to Emporia (Kansas) | 1,237.64 mi (1,991.80 km) |
| Rancho Santa Margarita to Encinitas (California) | 44.73 mi (71.98 km) |
| Rancho Santa Margarita to Endicott (New York) | 2,315.54 mi (3,726.50 km) |
| Rancho Santa Margarita to Endwell (New York) | 2,317.71 mi (3,729.99 km) |
| Rancho Santa Margarita to Englewood (Colorado) | 811.89 mi (1,306.61 km) |
| Rancho Santa Margarita to Englewood (Florida) | 2,141.51 mi (3,446.43 km) |
| Rancho Santa Margarita to Englewood (New Jersey) | 2,424.95 mi (3,902.58 km) |
| Rancho Santa Margarita to Englewood (Ohio) | 1,881.15 mi (3,027.42 km) |
| Rancho Santa Margarita to Enid (Oklahoma) | 1,130.62 mi (1,819.56 km) |
| Rancho Santa Margarita to Ennis (Texas) | 1,216.36 mi (1,957.54 km) |
| Rancho Santa Margarita to Ensley (Florida) | 1,781.91 mi (2,867.71 km) |
| Rancho Santa Margarita to Enterprise (Alabama) | 1,850.33 mi (2,977.82 km) |
