| Rancho Santa Margarita to Elkhart (Indiana) | 1,806.02 mi (2,906.51 km) |
| Rancho Santa Margarita to Elkhorn (Wisconsin) | 1,687.56 mi (2,715.87 km) |
| Rancho Santa Margarita to Elko (Nevada) | 507.96 mi (817.48 km) |
| Rancho Santa Margarita to Elkridge (Maryland) | 2,284.43 mi (3,676.43 km) |
| Rancho Santa Margarita to Elkton (Maryland) | 2,331.96 mi (3,752.93 km) |
| Rancho Santa Margarita to Ellensburg (Washington) | 936.43 mi (1,507.04 km) |
| Rancho Santa Margarita to Ellicott City (Maryland) | 2,279.21 mi (3,668.03 km) |
| Rancho Santa Margarita to Elmhurst (Illinois) | 1,707.30 mi (2,747.64 km) |
| Rancho Santa Margarita to Elmira (New York) | 2,277.30 mi (3,664.96 km) |
| Rancho Santa Margarita to Elmont (New York) | 2,439.43 mi (3,925.89 km) |
| Rancho Santa Margarita to Elmwood Park (Illinois) | 1,714.03 mi (2,758.46 km) |
| Rancho Santa Margarita to Elmwood Park (New Jersey) | 2,417.27 mi (3,890.22 km) |
| Rancho Santa Margarita to Elon (North Carolina) | 2,152.33 mi (3,463.83 km) |
| Rancho Santa Margarita to Eloy (Arizona) | 352.20 mi (566.81 km) |
| Rancho Santa Margarita to Elwood (New York) | 2,458.22 mi (3,956.13 km) |
