| Rancho Santa Margarita to El Segundo (California) | 50.15 mi (80.71 km) |
| Rancho Santa Margarita to El Sobrante (California) | 18.38 mi (29.58 km) |
| Rancho Santa Margarita to Eldersburg (Maryland) | 2,272.44 mi (3,657.14 km) |
| Rancho Santa Margarita to Elfers (Florida) | 2,090.69 mi (3,364.64 km) |
| Rancho Santa Margarita to Elgin (Illinois) | 1,689.75 mi (2,719.39 km) |
| Rancho Santa Margarita to Elizabeth (New Jersey) | 2,414.25 mi (3,885.36 km) |
| Rancho Santa Margarita to Elizabeth City (North Carolina) | 2,331.58 mi (3,752.32 km) |
| Rancho Santa Margarita to Elizabethton (Tennessee) | 1,999.38 mi (3,217.69 km) |
| Rancho Santa Margarita to Elizabethtown (Kentucky) | 1,793.96 mi (2,887.09 km) |
| Rancho Santa Margarita to Elizabethtown (Pennsylvania) | 2,289.07 mi (3,683.90 km) |
| Rancho Santa Margarita to Elk City (Oklahoma) | 1,040.03 mi (1,673.77 km) |
| Rancho Santa Margarita to Elk Grove (California) | 392.36 mi (631.44 km) |
| Rancho Santa Margarita to Elk Grove Village (Illinois) | 1,706.12 mi (2,745.74 km) |
| Rancho Santa Margarita to Elk Plain (Washington) | 959.52 mi (1,544.20 km) |
| Rancho Santa Margarita to Elk River (Minnesota) | 1,506.22 mi (2,424.02 km) |
