| Rancho Santa Margarita to Effingham (Illinois) | 1,652.22 mi (2,659.00 km) |
| Rancho Santa Margarita to Eggertsville (New York) | 2,178.51 mi (3,505.97 km) |
| Rancho Santa Margarita to Egypt Lake-Leto (Florida) | 2,107.64 mi (3,391.91 km) |
| Rancho Santa Margarita to El Cajon (California) | 68.20 mi (109.76 km) |
| Rancho Santa Margarita to El Campo (Texas) | 1,291.67 mi (2,078.74 km) |
| Rancho Santa Margarita to El Centro (California) | 131.56 mi (211.73 km) |
| Rancho Santa Margarita to El Cerrito (California) | 396.48 mi (638.07 km) |
| Rancho Santa Margarita to El Dorado (Arkansas) | 1,434.67 mi (2,308.88 km) |
| Rancho Santa Margarita to El Dorado (Kansas) | 1,195.90 mi (1,924.61 km) |
| Rancho Santa Margarita to El Dorado Hills (California) | 398.00 mi (640.51 km) |
| Rancho Santa Margarita to El Mirage (Arizona) | 303.32 mi (488.15 km) |
| Rancho Santa Margarita to El Monte (California) | 39.28 mi (63.21 km) |
| Rancho Santa Margarita to El Paso (Texas) | 660.34 mi (1,062.72 km) |
| Rancho Santa Margarita to El Paso de Robles (California) | 222.34 mi (357.83 km) |
| Rancho Santa Margarita to El Reno (Oklahoma) | 1,122.64 mi (1,806.72 km) |
