| Rancho Santa Margarita to Eatontown (New Jersey) | 2,422.68 mi (3,898.92 km) |
| Rancho Santa Margarita to Eau Claire (Wisconsin) | 1,586.63 mi (2,553.43 km) |
| Rancho Santa Margarita to Echelon (New Jersey) | 2,374.80 mi (3,821.87 km) |
| Rancho Santa Margarita to Eden (North Carolina) | 2,136.35 mi (3,438.12 km) |
| Rancho Santa Margarita to Eden Prairie (Minnesota) | 1,497.77 mi (2,410.42 km) |
| Rancho Santa Margarita to Edgewater (Florida) | 2,176.85 mi (3,503.29 km) |
| Rancho Santa Margarita to Edgewater (New Jersey) | 2,425.13 mi (3,902.87 km) |
| Rancho Santa Margarita to Edgewood (Maryland) | 2,307.38 mi (3,713.36 km) |
| Rancho Santa Margarita to Edgewood (Washington) | 970.89 mi (1,562.50 km) |
| Rancho Santa Margarita to Edina (Minnesota) | 1,503.39 mi (2,419.47 km) |
| Rancho Santa Margarita to Edinburg (Texas) | 1,265.67 mi (2,036.90 km) |
| Rancho Santa Margarita to Edmond (Oklahoma) | 1,153.70 mi (1,856.70 km) |
| Rancho Santa Margarita to Edmonds (Washington) | 1,010.35 mi (1,626.00 km) |
| Rancho Santa Margarita to Edwards (Colorado) | 735.31 mi (1,183.37 km) |
| Rancho Santa Margarita to Edwardsville (Illinois) | 1,573.54 mi (2,532.37 km) |
