| Rancho Santa Margarita to East Providence (Rhode Island) | 2,557.72 mi (4,116.25 km) |
| Rancho Santa Margarita to East Rancho Dominguez (California) | 38.80 mi (62.45 km) |
| Rancho Santa Margarita to East Renton Highlands (Washington) | 984.39 mi (1,584.22 km) |
| Rancho Santa Margarita to East Ridge (Tennessee) | 1,841.65 mi (2,963.85 km) |
| Rancho Santa Margarita to East Riverdale (Maryland) | 2,276.39 mi (3,663.50 km) |
| Rancho Santa Margarita to East San Gabriel (California) | 43.32 mi (69.72 km) |
| Rancho Santa Margarita to East St. Louis (Illinois) | 1,564.92 mi (2,518.50 km) |
| Rancho Santa Margarita to East Wenatchee (Washington) | 962.70 mi (1,549.32 km) |
| Rancho Santa Margarita to Eastern Goleta Valley (California) | 137.34 mi (221.03 km) |
| Rancho Santa Margarita to Eastlake (Ohio) | 2,038.42 mi (3,280.52 km) |
| Rancho Santa Margarita to Eastmont (Washington) | 1,013.90 mi (1,631.71 km) |
| Rancho Santa Margarita to Easton (Maryland) | 2,322.39 mi (3,737.52 km) |
| Rancho Santa Margarita to Easton (Pennsylvania) | 2,360.29 mi (3,798.52 km) |
| Rancho Santa Margarita to Eastpointe (Michigan) | 1,966.09 mi (3,164.12 km) |
| Rancho Santa Margarita to Eastvale (California) | 22.82 mi (36.72 km) |
