| Rancho Santa Margarita to East Lake (Florida) | 2,094.89 mi (3,371.40 km) |
| Rancho Santa Margarita to East Lake-Orient Park (Florida) | 2,116.22 mi (3,405.72 km) |
| Rancho Santa Margarita to East Lansing (Michigan) | 1,891.07 mi (3,043.39 km) |
| Rancho Santa Margarita to East Los Angeles (California) | 42.87 mi (69.00 km) |
| Rancho Santa Margarita to East Massapequa (New York) | 2,453.76 mi (3,948.95 km) |
| Rancho Santa Margarita to East Meadow (New York) | 2,447.09 mi (3,938.21 km) |
| Rancho Santa Margarita to East Milton (Florida) | 1,798.10 mi (2,893.76 km) |
| Rancho Santa Margarita to East Moline (Illinois) | 1,578.56 mi (2,540.45 km) |
| Rancho Santa Margarita to East Niles (California) | 141.69 mi (228.02 km) |
| Rancho Santa Margarita to East Northport (New York) | 2,458.92 mi (3,957.26 km) |
| Rancho Santa Margarita to East Orange (New Jersey) | 2,412.88 mi (3,883.16 km) |
| Rancho Santa Margarita to East Palo Alto (California) | 367.67 mi (591.71 km) |
| Rancho Santa Margarita to East Patchogue (New York) | 2,477.15 mi (3,986.59 km) |
| Rancho Santa Margarita to East Peoria (Illinois) | 1,611.88 mi (2,594.07 km) |
| Rancho Santa Margarita to East Point (Georgia) | 1,897.08 mi (3,053.06 km) |
