| Rancho Santa Margarita to Eagan (Minnesota) | 1,510.30 mi (2,430.60 km) |
| Rancho Santa Margarita to Eagle (Idaho) | 700.22 mi (1,126.90 km) |
| Rancho Santa Margarita to Eagle Mountain (Utah) | 554.93 mi (893.08 km) |
| Rancho Santa Margarita to Eagle Pass (Texas) | 1,065.76 mi (1,715.18 km) |
| Rancho Santa Margarita to Easley (South Carolina) | 1,991.93 mi (3,205.71 km) |
| Rancho Santa Margarita to East Bakersfield (California) | 144.14 mi (231.97 km) |
| Rancho Santa Margarita to East Bethel (Minnesota) | 1,523.03 mi (2,451.08 km) |
| Rancho Santa Margarita to East Chicago (Indiana) | 1,729.37 mi (2,783.15 km) |
| Rancho Santa Margarita to East Cleveland (Ohio) | 2,030.26 mi (3,267.38 km) |
| Rancho Santa Margarita to East Glenville (New York) | 2,425.00 mi (3,902.66 km) |
| Rancho Santa Margarita to East Grand Rapids (Michigan) | 1,836.93 mi (2,956.26 km) |
| Rancho Santa Margarita to East Hemet (California) | 38.43 mi (61.84 km) |
| Rancho Santa Margarita to East Highland Park (Virginia) | 2,258.16 mi (3,634.15 km) |
| Rancho Santa Margarita to East Honolulu (Hawaii) | 2,584.44 mi (4,159.26 km) |
| Rancho Santa Margarita to East Islip (New York) | 2,466.60 mi (3,969.60 km) |
