| Rancho Santa Margarita to Dixon (California) | 407.85 mi (656.37 km) |
| Rancho Santa Margarita to Dixon (Illinois) | 1,628.91 mi (2,621.47 km) |
| Rancho Santa Margarita to Dobbs Ferry (New York) | 2,430.02 mi (3,910.75 km) |
| Rancho Santa Margarita to Doctor Phillips (Florida) | 2,156.30 mi (3,470.24 km) |
| Rancho Santa Margarita to Dodge City (Kansas) | 1,025.12 mi (1,649.76 km) |
| Rancho Santa Margarita to Dolton (Illinois) | 1,721.85 mi (2,771.05 km) |
| Rancho Santa Margarita to Donna (Texas) | 1,277.00 mi (2,055.14 km) |
| Rancho Santa Margarita to Dorado (Puerto Rico) | 3,317.57 mi (5,339.11 km) |
| Rancho Santa Margarita to Doral (Florida) | 2,285.90 mi (3,678.80 km) |
| Rancho Santa Margarita to Doraville (Georgia) | 1,905.77 mi (3,067.04 km) |
| Rancho Santa Margarita to Dothan (Alabama) | 1,877.07 mi (3,020.85 km) |
| Rancho Santa Margarita to Douglas (Arizona) | 495.02 mi (796.66 km) |
| Rancho Santa Margarita to Douglas (Georgia) | 2,018.97 mi (3,249.22 km) |
| Rancho Santa Margarita to Douglasville (Georgia) | 1,882.97 mi (3,030.35 km) |
| Rancho Santa Margarita to Dover (Delaware) | 2,349.92 mi (3,781.83 km) |
